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These pivotal studies evaluated semaglutide's efficacy and safety across diverse patient populations, including those with varying diabetes duration, renal impairment, and cardiovascular risk profiles

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Figure 3 ), enhancing bone mass and strength in preclinical models of T2DM (120), and is thought to play an important role in enhancing cognition ( (121)

Tirzepatide-Specific Considerations Tirzepatide appears to have slightly higher rates of GI side effects compared to Semaglutide in head-to-head trials, though discontinuation rates remain relatively low