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This article covers mechanism, clinical trial evidence, FDA-approved indications, boxed-warning safety, and the FTO, GLP1R, MC4R, and TCF7L2 variants that shape every GLP-1 response

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In the past two years, Ive spent time assessing and working with and through the phenomenon of GLP-1s in health care through the consumer lens and how this category of prescription drugs are profoundly impacting many segments of the U.S

However, gastrointestinal side effects related to GLP-1 RA need appropriate clinical management to mitigate risks and maximize the benefits of therapy in people with IBD