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Description
This was observed in the SURPASS-1 trial

However, after stopping the medication, you may notice increased appetite or gradual changes in metabolism as hormone regulation returns to its natural state
A disproportionality analysis (Godfrey et al., JEADV 2025) found a reporting odds ratio of 1.73 for tirzepatide (95% CI: 1.42 to 2.09), and as high as 2.46 for semaglutide

For instance, data on Mounjaro vs Wegovy side effects suggests that while both effectively manage weight, their tolerability profiles diverge significantly during the first few months of treatment

If you normally inject in the abdomen, switch to the thigh , or vice versa

Throbbing, often one-sided pain that can last hours or days
