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Providers should track A1C, body weight, renal function, and gastrointestinal tolerance

Adverse events In the STEP-1 trial, the rate of GI adverse events was 1.5 times higher in the semaglutide group vs

Patients should discuss any thyroid symptoms with their healthcare provider (as a precaution based on animal studies)

That could be because GIP may help improve insulin sensitivity more alongside GLP-1, a metabolic edge semaglutide doesnt fully match

Can retatrutide replace diet and exercise

Endogenous GLP-1 levels have been shown to be lower in the follicular phase compared with the luteal phase ( Concomitant use of GLP-1 and estradiol conjugates has been primarily limited by the oncogenic and gynecological side-effects that have been attributed to estrogens