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In my experience looking at the data, tirzepatide in particular is producing results that were unthinkable from a weight loss drug five years ago

Gut 59 , 12591264 (2010)

doi: 10.3390/cimb47040285 [DOI] [PMC free article] [PubMed] [Google Scholar] 129.Garca-Casares N, Gonzlez-Gonzlez G, De La Cruz-Cosme C, et al

The ADA also recommends the use of a GLP-1RA and/or a sodium-glucose cotransporter-2 inhibitor independent of metformin use in patients with known chronic kidney disease, cardiovascular disease, or risk factors for cardiovascular disease [3]

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