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These considerations motivate a shift from purely pathway-centric models to spatiotemporally quantitative frameworks that track receptor dwell time, contact-site turnover, and local second-messenger dynamics in real time

Metformin works through a distinct pathway, primarily improving insulin sensitivity in muscle and liver cells while reducing glucose production in the liver

Structure-Activity Relationship (SAR) studies further support its potential as a source for future drug development

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[DOI] [PMC free article] [PubMed] [Google Scholar] 618.Pop-Busui R, Cleary PA, Braffett BH, et al