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GLP-1 Effects on Skeletal Muscle Increasing GLP-1 activity, through endogenous or exogenous GLP-1 or GLP-1R agonists, increases glycogen synthesis and glucose uptake in skeletal muscle via AMP-activated protein kinase (AMPK) activation [96]

Mean HbA1c decreased from 9.06 1.69% to 8.75 2.48% (0.31 2.57%

doi: 10.1016/j.jacc.2022.11.005 2 MarxNHusainMLehrkeMVermaSSattarN

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While DHEA is widely considered to have anti-glucocorticoid effects, the mechanisms underlying these effects are unclear

19 Conclusion These reports suggest the potential utility of GLP-1 analogs in the treatment of dermatologic disease