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Quinine induces GLP-1 secretion in human enteroendocrine NCI-H716 cells

A total of 11,016 matched IBD patients were included (GLP-1 RAs: n = 5508

Glucagon-like peptide-1 (GLP-1) receptor agonists, FDA-approved medications for type 2 diabetes and weight management, have recently sparked interest for an unexpected effect: some patients report reduced desire to drink alcohol while taking these drugs

Of 53,943 patients screened, 1,021 met inclusion criteria

One study reported that 43.8% of participants who discontinued treatment did so due to nausea and vomiting, while 36.8% stopped because of gastrointestinal discomfort [14]

Finally, we introduce the potential of L-cell differentiation as an attractive future therapeutic approach to increase GLP-1 production as an attractive therapeutic alternative for T2DM