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Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously a mechanism that sets it apart from existing licensed treatments

Yu X, Tang H, Huang L, Yang Y, Tian B, and Yu C

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Leptin and gene therapy Leptin has been recognized as one of the therapeutic candidates for obesity and as a regulator of fat mass, but its therapeutic effect is limited because of the apparent development of leptin resistance and the decreased BBB transport that is, observed in obese subjects with elevated blood leptin levels