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Many patients benefit from a temporary dose reduction or a switch to a lower-potency formulation while their body resets

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In the last three decades, the incretin-effect has been attributed primarily to two peptide hormones, the gastric-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), excreted primarily by duodenal (K) and ileo-colonic (L) enteroendocrine cells respectively (14)

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Minimal and maximal signals were recorded in the presence of 5 m ionomycin in 5 mm EGTA/0 mm Ca 2+ and 5 mm Ca 2+ , respectively, at the end of the experiment