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[DOI] [PubMed] [Google Scholar] 186.Pratley RE, Nauck M, Bailey T, Montanya E, Cuddihy R, Filetti S, Thomsen AB, Sondergaard RE, Davies M

Dual strategies that address both metabolic disorders and depression simultaneously appear reasonable

The slow dissociation rate and significant receptor affinity prolong the pharmacological effect [233], [234]

3 Safety & Tolerability Under the Microscope Injection-site reactions were notable: 12% with CagriSema 17% with cagrilintide alone 2.6% with semaglutide alone While overall discontinuation remained low (~1%), tolerability will be a key differentiator versus Lillys portfolio

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