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These agents exhibit anti-inflammatory, cardioprotective, and neuroprotective effects, suggesting a broader therapeutic potential

doi: 10.1517/14656566.7.15.2095 143 PedrosaMRFrancoDRGieremekHWVidalCMBronzeriFde Cassia RochaAet al

14-15 It is important to note that obesity is a chronic disease, and discontinuing semaglutide can lead to weight regain due to a decrease in lean mass and basal metabolic rate (BMR)

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In addition, two large-scale, double-blind, placebo-controlled phase 3 clinical studies called Evoke and Evoke + are underway to investigate the disease-mitigating potential of semaglutide in patients with AD with early symptoms and to explore its effects on AD biomarkers and neuroinflammation (Cummings et al., 2025)

In another study, intraperitoneal injection with GLP-1 analogue (Val)GLP-1 enhances neuronal stem cells and neurogenesis in the dentate gyrus of brain in wild type mice, so it may have potentially beneficial effects in the CNS (167)