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Development of GLP-1 receptor agonists The most important strategy to develop compounds with extended in vivo half-life of GLP-1 was by making DPP-4 resistant GLP-1 receptor agonists

39 , e3673 (2023)
Available from: GLP-1 medicines for weight loss and diabetes: what you need to know [Internet]

As such, the AMYR agonists (combined with other incretin class members) could represent the elusive drug candidate to address the multi-hormonal dysregulations of diabetes subtypes and qualify as a precision medicine approach that surpasses the long overdue division into T1DM and T2DM

This exclusion is significant considering that patients with obesity have a higher risk of developing depression 24
