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Research shows that once the medication is stopped, weight regain is common, often rapid, because the underlying drivers remain untouched (Quarenghi et al

However, the existing evidence is limited by small cohort sizes, heterogeneous patient populations, and confounding effects of concurrent therapies, limiting its generalizability

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Aims/hypothesis Metformin is the only approved oral agent for youth with type 2 diabetes but its mechanism of action remains controversial

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