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Phentermine costs $10-$40 monthly, naltrexone-bupropion ranges $60-$200 monthly, and orlistat costs $40-$80 monthly

Constipation: This is also reported more frequently with the oral version than the injectable

In addition, more than a third of participants lost at least 25% of their starting body weight

For context, NICE guidance on obesity pharmacotherapy including TA875 (semaglutide for weight management) and TA924 (tirzepatide for managing overweight and obesity) provides a useful framework for understanding how future agents might be positioned in the UK

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