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Neuronal expression of GLP-1RAs is important for weight loss actions, signifying that these receptors mediate satiety and suppress food intake through appetite-suppressing circuits in the hypothalamus and other areas [30,35,36]
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However, SGLT2 inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria, because it elicits an adaptive increase in energy intake, including compensatory increases in appetite/caloric intake [40]
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Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward
