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To determine the pharmacodynamic profile of serum total testosterone and luteinizing hormone (LH) levels in men with secondary hypogonadism after initial and chronic daily oral doses of enclomiphene citrate vs transdermal testosterone

HRS9531-301).

Patients should be counselled to maintain adequate hydration and carbohydrate intake, and to seek urgent medical advice if they develop persistent vomiting, poor oral intake, abdominal pain, weakness, or rapid deterioration

The real opportunity now lies in innovation, affordability, and global collaboration

This Review outlines the current landscape of obesity drug development, focusing on glucagon-like peptide 1 receptor agonists, multi-receptor agonists, amylin receptor agonists and next-generation oral therapies

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