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In a randomized controlled trial assessing the effects of butyrate in obese children, there was a consistent response which showed a significant reduction of bodyweight and waist circumference compared to placebo [4]. Per-protocol analysis in the butryate group revealed a decrease in BMI of 2.26 units and a reduction in waist circumference by 5.07cm in 6 months [4]

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Yes, clinical evidence shows that semaglutide often improves liver enzyme levels in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

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NHS guidelines: NHS access would depend on clinical guidelines and cost-effectiveness reviews following regulatory approval