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Funding: This study was supported by the Department of Veterans Affairs via grant BX004299 (to RS Peebles Jr)

This isnt just about getting thinner

SGLT2i have a Class of Recommendation 2a in HF with mildly reduced ejection fraction (HFmrEF)

This contributes to adipose tissue dysfunction, whereas WAT inflammation and oxidative stress supervene, promoting the release of pro-inflammatory adipokines, leptin and adiponectin, along with enormous levels of cytokines (IL-6, IL-1b, TNF-) and NF-B activation, all ending in a cycle of sustained systemic insulin-resistant state [36,98,99,100]

semaglutide users in cohort 1 most frequently received 0.25 mg (61%) or 0.5 mg (29%) at first dispensation