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Also, because I think it's simple, once a week injection and the needles are so small, obviously there are people who really have needle phobia, but take those aside, it's relatively few

[DOI] [PubMed] [Google Scholar] 60.Thulesen J, Hartmann B, rskov C, Jeppesen PB, Holst JJ, Poulsen SS

GLP-1 receptor agonists have known satiety-promoting effects due to central action of the neuropeptide GLP-1 [1], with reduced activation of appetite- and reward-related brain areas in response to food [18]

The data suggest that GLP-1-induced weight loss includes both fat mass and lean mass reduction, with approximately 25-40% of total weight loss coming from lean tissue

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Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression