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Second, the canonical TLR4 pathway is now shown to be a crucial driver of the signals linking LPS to the stimulation of GLP-1 secretion

That's good news for makers of the GLP-1 drugs, including Eli Lilly (LLY +0.85%) and Novo Nordisk (NVO 2.31%), which make the best-selling GLP-1 weight loss drugs

And indeed, a number of bitter compounds have been shown to potently stimulate the release of hormones like GLP-1 in petri dishes and lab animals

This blog draws from insights shared during our recent webinar on payer perspectives on GLP-1 therapies, using data from our 2025 Trends in Drug Benefit Design Report