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Objective Investigate the association between GLP-1RAs use and intestinal obstruction in a large cohort of patients with type 2 diabetes mellitus (T2DM) in the U.S

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Although some amelioration of inflammation has been seen, these drugs did not improve the fibrosis component of NASH

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In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.