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Understanding these secondary effects helps distinguish normal physiological adaptations from symptoms requiring medical attention

Borato DC, Parabocz GC, Ribas JT et al (2016) Biomarkers in obesity: serum myeloperoxidase and traditional cardiac risk parameters

Originally FDA-approved to treat diabetes, they turned out to produce notable weight loss as well, reducing appetite, increasing metabolism and fat burning, and lowering BMI

Numerous studies examining the relationship between artificial sweeteners and cancer are observational, meaning they can reveal patterns but cannot establish a direct cause-and-effect relationship

What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease

The most commonly reported adverse effects are gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation