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Description
The early divergence of the MACE occurrence curves between the SEMA and placebo groups23 suggests that SEMA may have been directly involved in the SELECT study results through its effects on angiogenesis, reduction of oxidative stress and inflammation, and anti-atherogenic actions derived from GLP-1R activation that promote endothelial function and cell survival7 (Fig

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While all GLP-1 medications effectively lower hemoglobin A1c and promote weight loss, they differ in dosing frequency, formulation, cardiovascular benefits, and side effect profiles

10.1016/S2213-8587(19)30249-9

To date, preclinical HFpEF models have primarily utilized single perturbations to replicate the human HFpEF phenotype
Funding This work was supported by Statutory Funds of the Laboratory of Immunoendocrinology, Maj Institute of Pharmacology, Cracow, Poland