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doi: 10.1056/NEJMoa0806470 [DOI] [PubMed] [Google Scholar] 4

Discovery and characterization of the incretin hormones Discovery and characterization of the incretin hormones Trust your gut

Semaglutide and tirzepatide are both glucagon-like peptide-1 receptor agonists or GLP-1 agonists

Beginning at lower doses allows your body to adapt and minimizes side effects, but may delay peak appetite suppression compared to rapid escalation protocols
Insulin doses may need to be adjusted, especially mealtime insulin, but insulin remains essential

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