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This, teamed with Asias openness to new technologies and a desire for a solution for weight management that actually works, add credence to the argument that GLP-1s will be well-received across this market, says Forsyth

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The typical escalation moves from 0.25 mg to 0.5 mg at week 5, then to 1 mg at week 9, followed by 1.7 mg at week 13, and finally reaching the full maintenance dose of 2.4 mg semaglutide with 2.4 mg cagrilintide at week 17

Discussion The GLP-1-based therapies usually utilize two strategies: 1) inhibition of dipeptidyl peptidase 4 (DPP-4) enzyme with specific inhibitors, such as sitagliptin / vildgliptin, in order to raises plasma levels of endogenous GLP-1 and GIP and 2) utilizing DPP-4 resistant GLP-1 receptor agonists, such as liraglutide / exenatide 44