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Fourth, time and method of GLP-1 RA administration varied largely across studies, and it still remains unclear whether there are differences between the efficacy of short-term GLP-1 infusion and longer-term oral administration of GLP-1 RAs (Subaran et al., 2014

Hayes MR, Borner T, De Jonghe BC

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PLoS ONE 8 , e76520 (2013)

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[2] [11] As of 2026, retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it remains an experimental compound available only within authorised clinical trial settings