glp 1 agonist effects GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes glp-1_analogs [TUSOM | Pharmwiki]

E., Sallis, J

doi: 10.1007/s11064-008-9646-4 28 AnFMChenSXuZYinLWangYLiuARet al

We compared the use of GLP-1RAs with second- or third-line glucose-lowering therapy to minimise confounding [22], thereby allowing us to explore the impact of including a reference group with the same disease stage, even though we adjusted for microvascular complications

Endocrinology (2004) 145:268795

This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)

GLP-1RAs promote weight loss by reducing appetite via slowed gastric emptying and acting on the brains appetite centres