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A recent meta-analysis of six studies involving 2071 participants found that GLP-1 RA treatment significantly reduced depression rating scale scores compared to control treatments (standardized mean difference, 0.12

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7 PIONEER 7 The PIONEER 7 trial, like PIONEER 3, compared oral semaglutide against 100-mg sitagliptin, although this trial differs in that it allowed for flexible dose adjustments of oral semaglutide

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This must be evaluated within the broader clinical context of metabolic benefitfertility windowdiscontinuation risk management (98)

After removing the duplicates and retracting the studies, all were pooled and selected for inclusion in the meta-analysis based on their titles or abstracts