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Instead, people with diabetes should prioritize lean protein sources, fruits and vegetables, and whole grains while limiting their intake of sweets and fatty foods

These may include ones that combine other components with GLP-1, like tirzepatide does, or ones that work to mimic other gut hormones with different qualities

Phase 2 data shows 24.2 percent weight loss over 48 weeks at the 12 mg dose, the largest reported for any peptide in the class

The use of these drugs could lead to a shift in treatment strategies, where healthcare providers may prioritize GLP-1s not only for their diabetic effects but also as a preventive measure against clots

Dehydration and acute kidney injury risk is elevated with persistent gastrointestinal losses, particularly in older adults or those taking diuretics or RAAS-blocking medicines

The results of RT-qPCR indicated that GLP-1RAs downregulated the expression of IL-6 , TNF- , and iNOS , and upregulated the expression of IL-10 , TGF- , and Arg-1 (Fig