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For detailed storage guidance, see our guide on how long tirzepatide lasts in the fridge

As tirzepatides GLP-1 and GIP effects wear off, digestion speeds back up, and appetite increases

Others are imposing a two-year limit on coverage, Lee said

Splitting a dose requires two needle punctures, increasing contamination risk and injection site reactions

While GLP-1 primarily mediates glucose-dependent insulin secretion and appetite suppression, GIP influences insulin secretion and, based on preclinical studies, may affect lipid metabolism and other metabolic pathways

Common injection sites include stomach (abdomen), thighs, and upper arms