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Improving insulin resistance by sulforaphane via activating the bacteroides and lactobacillus SCFAs-GPR-GLP1 signal axis

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Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected as new entrants including Boehringer Ingelheim, Amgen, Pfizer and Roche offer novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly)

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Growth hormone acts directly on adipose tissue through lipolytic pathways, breaking down stored triglycerides

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SAU and JR contributed to data collection

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