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In an in vivo experiment, semaglutide was found to decrease seizure severity, reduce neuronal damage and ameliorate cognitive impairment, potentially via inhibition of NLRP3 inflammasome activation and related cascade reactions

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Two distinct types of neurons within the ARC, proopiomelanocortin (POMC) and Neuropeptide Y (NPY)/Agouti gene-related peptide (AgRP) neurons, play important roles in energy balance and glucose homeostasis (Gautron et al., 2015

GLP-1 receptor agonists activate brain regions controlling reward, motivation, and dopamine signalingthe same systems reinforced by nicotine
