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Alterations in Vd resulting from reduced fat mass and alterations in clearance resulting from changes in CYP activity and GFR are key factors in determining pharmacokinetics

Harvard Kumar Malesu, Vijay

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30 , e13313 (2018)

Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

161 Unlike other pharmacodynamic effects, such as lowering blood glucose or reducing appetite, the delay in gastric emptying shows tachyphylaxis, with the effect gradually decreasing over time