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Persistence should not be judged by staying on a single drug indefinitely, but by maintaining engagement in care and working with clinicians to find sustainable, effective treatment strategies over time, she said in a news release

Fortunately, GLP1 medications are now FDA-indicated for multiple indications beyond weight management and diabetes, including: Major cardiovascular event (heart attack and/or stroke) risk reduction in adults with cardiovascular disease and overweight or obesity Metabolic dysfunctionassociated steatohepatitis (MASH) Moderate to severe obstructive sleep apnea (OSA) in adults with obesity When one medication can address multiple conditions, it simplifies care and reduces polypharmacy

The combination has to be screened for phentermines cardiovascular contraindications and topiramates renal and cognitive effects, plus the additive nausea risk of GLP-1 plus topiramate

Those drugs mimic this hormone in a more sustained way than your body can on its own, since natural GLP-1 only sticks around in your bloodstream for a couple of minutes

Focus instead on lean proteins, fiber-rich carbs, and moderate healthy fats spread across smaller meals
