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Key points Cardiovascular outcome trials in individuals with type 2 diabetes mellitus demonstrate that glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists reduce the rates of non-fatal myocardial infarction, non-fatal stroke and cardiovascular death

In studies of GLP-1 receptor agonists used alone or in combination with oral antihyperglycemic therapies, mean changes in A1C ranged from 0.8 to 1.7% for exenatide BID, 0.8 to 1.5% for liraglutide 1.21.8 mg once daily, 0.6 to 0.9% for lixisenatide once daily, 0.6 to 0.9% for albiglutide 3050 mg QW, 0.7 to 1.6% for dulaglutide 0.751.5 mg QW, and 1.3 to 1.6% for exenatide QW (1318)

Understanding how Ozempic works, its intended uses, and the considerations that come with its prescription is crucial for anyone on a medically supervised weight loss or diabetes management journey

Semaglutide is a versatile medication that helps manage type 2 diabetes and supports weight loss

So with weight loss, Id assume that my VO2 max would improve

Long-term use may be necessary to maintain weight loss, as discontinuation can lead to weight regain