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Similarly, arcuate proopiomelanocortin neurons also receive an indirect enhanced excitatory tone in response to GLP1 receptor agonism (He et al., 2019)

GIP Receptor Activation Glucose-dependent insulinotropic polypeptide receptors add a second layer of metabolic influence

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Retatrutide is an investigational weight loss medication that targets GLP-1, GIP, and glucagon receptors, potentially making it more effective than tirzepatide, which only targets GLP-1 and GIP