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History of pancreatitis : GLP-1 agonists may increase the risk of pancreatitis in some individuals

Studies such as the LEADER trial (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have shown reductions in major adverse cardiovascular events, including heart attack and stroke, in people with type 2 diabetes and established cardiovascular disease or high cardiovascular risk

While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss

Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report

This suggests a direct effect on the adaptive immune response driving MS

Efficacy and Safety of Efpeglenatide in Patients with Type 2 Diabetes and Obesity: a Systematic Review