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Cardiovascular protection builds over years
Do ODTs cause fewer side effects than injections
A 2026 PMC review (PMC 12904723) characterized GLP-1 side effects as follows: GI events are the most prevalent but are "typically transient and dose-dependent." No new safety signals have been identified, and the National Institutes of Health (NIH) continues to fund long-term outcome studies have emerged from long-term data up to 5 years
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After her weight rose from about 50kg at university to 72kg in 2024, the medication helped her lose about 8kg in the first six months, bringing her weight down to about 60kg

Oral orfoglipron, as opposed to peptide-based oral semaglutide, can be taken without regard to food timing