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E.LakshmananM.et al (2020)

Researchers who escalated too quickly bore the brunt of gastrointestinal side effects, while those who followed the standard four-week titration intervals reported significantly better tolerability

GLP-1s for Psoriasis: How Do They Help

They not only exacerbate hyperglycemia in patients with known diabetes mellitus (DM), but also cause DM in patients without documented hyperglycemia before the initiation of glucocorticoids (GC) therapy[1,6], with an incidence that can reach up to 46% of patients, and increases in glucose levels up to 68% compared to baseline[7-9]

High-fat, high-cholesterol feeding decreased Dpp4 expression in F4/80 + cells, with only minor changes in immune signaling

There are also side effects to consider, as well as cost and lack of long term safety data - the longest study duration is 2 years - a far cry from the lifetime of use most folks will need to sign-up for to see sustained change