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Women carrying certain variants may experience more pronounced weight regain during pregnancy or faster weight loss postpartum, patterns that affect treatment planning across the reproductive lifecycle

Both passive glucose transport through the sodium-glucose cotransporter 1 (SGLT1) (158, 191) and active glucose transport through glucose transporter 2 (GLUT2) have been found to regulate intestinal GLP-1 secretion as inhibitors for each transporter blocks GLP-1 release (218)

The daily dosing of drops means more consistent blood levels throughout the week compared to the peak-and-trough pattern of weekly injections

Mice weight in the control group decreased from 30 0.5 g to 26 0.3 g, while in LEO (60 mg/kg) group it dropped to 24 0.3 g

We excluded the subjects having some endocrine disease and/or severe mental disorder

Metabolic Effects Beyond Weight Loss Both medication types improve metabolic markers, but dual agonists might offer some advantages in certain areas