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The weight loss figures from clinical trials for these three medications tell a compelling story, one where each generation of treatment meaningfully outperforms the last

Sometimes anxiety can be triggered by how the medication affects your bodylike changes in blood sugar, dehydration, or even just the stress of a new routine, says Eric Smith, DO, a bariatric surgeon and medical director at POP Recovery Systems

Explore Personalized Weight Loss Options Start with an online assessment to help a licensed clinician determine whether a prescription weight loss treatment, along with guided nutritional support, may be appropriate for you.

Accessed July 4, 2025

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Only 7% of participants stopped Retatrutide due to side effects at the 12mg dose