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Balaban YH, Korkusuz P, Simsek H, Gokcan H, Gedikoglu G, Pinar A, et al

In terms of mitochondrial function, GLP-1RAs act through multiple pathways: first, stimulating mitochondrial biogenesis via the AMPK signaling pathway to boost both the number and functionality of mitochondria (93)

FDA-approved labeling provides specific escalation schedules that should be followed carefully, with consideration for even slower titration in high-risk patients

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This metric looked at all prescriptions (not just first-time prescriptions, as we did with the overall population)

Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)