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The search strategy targeted studies involving GLP-1 receptor agonists (e.g., exenatide, liraglutide, dulaglutide, lixisenatide, benaglutide, loxenatide, semaglutide) and multi-target receptor agonists (e.g., tirzepatide), focusing on gastrointestinal adverse events (e.g., nausea, vomiting, diarrhea, constipation, dyspepsia, and reduced appetite) in patients with type 2 diabetes mellitus (T2DM) (Supplementary Material)

Eighty-five percent of those who took semaglutide lost at least 5 percent of their body weight over the course of the study, compared to just 26 percent of those who received the placebo

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Tirzepatide (Mounjaro, Zepbound) often costs about $1,050 to $1,350 per month

The 10mg went from about $92 to $85, an 89% decline, with a cheap floor holding around $55