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February 2025

Insulin levels during the glucose tolerance test were substantially lowered in the calorie-restricted mice and in mice treated with GLP-1MK-801 (Extended Data Fig

Rates of Acute Pancreatitis in GLP-1RA Use GLP-1RAs and dual GLP-1/GIPRAs are used to treat type 2 diabetes and, occasionally, for weight management and cardiovascular risk reduction

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49 Other good options include unsweetened herbal teas (ginger or peppermint tea may help with nausea) and, if needed for electrolyte replacement due to vomiting or diarrhea, low-sugar electrolyte drinks

Collectively, these findings highlight the dual capacity of GLP-1 RAs to reduce FBM while supporting skeletal muscle health, a distinction of clinical importance in the long-term management of obesity