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Two of the therapies highlighted in the Clarivate Drugs to Watch 2026 report, Sanofis tolebrutinib and Corcept Therapeutics relacorilant, faced such setbacks in the last days of 2025

Efficacy and side effect profiles are equivalent to brand medications, though individual responses vary

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Phase 2 trials documented average weight loss of 24.2% at the 12mg dose over 48 weeks, surpassing anything previously achieved through pharmaceutical intervention alone

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