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There are some gastrointestinal issues and a few serious side effects reported

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Obesity alone increases the risk of headache and migraine by 27%, suggesting that weight loss itself is an important goal in the symptomatic treatment of IIH (20)

Exendin-4 HMSC treatment with GLP-1-RA Exendin-4 (Ex-4), a 39 amino acid peptide originally isolated from Heloderma suspectum venom [14], did not have an influence on GLP-1 receptor nor hMSC surface receptor expression used for cell characterization [14, 15]

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