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The mean A1C reduction from a baseline of 8.28% was -2.01% (5 mg), -2.24% (10 mg), and -2.30% (15 mg) with tirzepatide versus -1.86% with semaglutide 1 mg
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Discontinuation of GLP1RAs and tirzepatide can also result in a loss of the beneficial anti-atherosclerotic and plaque-stabilizing effects of these medications
Wilson JM, Lin Y, Luo MJ, et al
39 In the SURMOUNT-1 and SURMOUNT-3 trials, the weight loss ranged between 15% and nearly 21% after 72 weeks of treatment
Yes, the clinical trial data suggest they produce very similar results
