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10.1007/s13238-018-0546-3 44 SunL.ShangB.LvS.LiuG.WuQ.GengY

May have higher risk of GI or metabolic side effects

With insulin syringes using fixed (non-detachable) needles, this dead space is minimal, around 0.003 mL or less

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Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]