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As we get to higher doses, the wall may become hypokinetic again due to ischemia and perfusion-contractile mismatch (e.g., the oxygen demand overwhelms the chronically hypoperfused area which has adapted to chronic ischemia by downregulating the intracellular contractile apparatus)

Hypoglycemia: Particularly in patients also taking insulin, low blood sugar episodes might be experienced

Kuchel O, Buu NT, Hamet P, Larochelle P (1985) Effect of metoclopramide on plasma catecholamine release in essential hypertension

doi: 10.1152/ajpendo.2001.281.1.E155

A common scenario: you think you reconstituted at 10 mg/mL but actually used 5 mL instead of 6 mL of water, creating a 12 mg/mL solution

van Deuren T, Blaak EE, Canfora EE